3.4. Follistatin 344 (1 mg)
""Follistatin is activin-binding protein is a protein that in humans is encoded by the FST gene. Clinical significance Follistatin is being studied for its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive muscle growth. In studies it is demonstrated that inhibition of GDF-8, either by genetic elimination (knockout mice) or by increasing the amount of follistatin, resulted in greatly increased muscle mass. Research with macaque monkeys demonstrated that regulating follistatin via gene therapy also resulted in muscle growth and increases in strength in 2009. This research paves the way for human clinical trials, which are hoped to begin in the summer of 2010 on Inclusion body myositis. A study with animal models has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy. It is also being investigated for its involvement in polycystic ovary syndrome, though there is debate as to its direct role in this infertility disease."
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