What is Sema Plus?
Sema Plus is a Glucagon-like peptide-1 receptor agonists, also known as GLP-1 receptor agonists
(GLP-1-RA) or incretin mimetics. Glucagon-like peptide 1 belongs to a family of hormones called
the incretins. It enhances the secretion of insulin due to factors derived from the gut. Glucagon-
like peptide 1 is a product of a molecule called pre-proglucagon, a polypeptide that is split to
produce many hormones, including glucagon. L-cells found in the lining of the small intestine
are the major source of glucagon-like peptide 1, although it is also secreted in smaller
quantities by the pancreas and the central nervous system. Glucagon-like peptide 1 encourages
the release of insulin from the pancreas, increases the volume of cells in the pancreas that
produce insulin (beta cells) and reduces the release of glucagon. The 2022 ADA standards of
medical care in diabetes include GLP-1-RA as a first line pharmacological therapy for type 2
diabetes, specifically in patients with atherosclerotic cardiovascular disease or obesity.
GLP-1 is an incretin hormone that plays a role in the appetite and digestion. Incretins are sent
out by the body after eating a meal. They help lower blood sugar by triggering insulin release
and blocking sugar production. They also slow down how quickly food leaves stomach (called
gastric emptying). Glucagon-like peptide 1 also increases the feeling of fullness during and
between meals by acting on appetite centers in the brain and by slowing the emptying of the
*Our bottles are in 3ml glass vials